2018-2020年度科研成果

题目

作者

期刊

发表时间

级别

15-Lipoxygenase/15-hydroxyeicosanoid   and activator protein 1 contribute to hypoxia-induced pulmonary artery smooth   muscle cells phenotype alteration

Yan Xing,   Xiaodong Zheng , Jing Qi , Yao Fu , Weiwei Cao , Jiali Li , Daling Zhu

Prostaglandins   Leukot Essent Fatty Acids

2018.08

SCI

5-BDBD   ameliorates an OVA-induced allergic asthma by the reduction of Th2 cytokines   production

Bing Hu ,   Xiaoqian Feng , Li Wang , Yinli Song , Xiuqin Ni

Iran J Basic Med   Sci

2018.04

SCI

Activation of   transient receptor potential vanilloid 3 channel (TRPV3) aggravated   pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats

Qianhui Zhang,   Hanping Qi , Yonggang Cao , Pilong Shi , Chao Song , Lina Ba , Yunping Chen ,   Jingquan Gao , Shuzhi Li , Baiyan Li , Hongli Sun

J Cell Mol Med

2018.12

SCI

Allicin improves the function of cardiac microvascular endothelial cells   by increasing PECAM-1 in rats with cardiac hypertrophy

Pilong Shi ,   Yonggang Cao , Jingquan Gao , Bowen Fu , Jing Ren , Lina Ba , Chao Song ,   Hanping Qi , Wei Huang , Xueying Guan , Hongli Sun

Phytomedicine

2018.12

SCI

The transient receptor potential vanilloid-3 regulates hypoxia-mediated pulmonary   artery smooth muscle cells proliferation via PI3K/AKT signaling pathway

Qianlong Zhang ,   Yonggang Cao , Qian Luo , Peng Wang , Pilong Shi , Chao Song , Mingyao E ,   Jing Ren , Bowen Fu , Hongli Sun

Cell Prolif

2018.06

SCI

Transient receptor potential vanilloid-3 (TRPV3) activation plays a   central role in cardiac fibrosis induced by pressure overload in rats via   TGF-β1 pathway

Yan Liu ,   Hanping Qi , Mingyao E , Pilong Shi , Qianhui Zhang , Shuzhi Li , Ye Wang ,   Yonggang Cao , Yunping Chen , Lina Ba , Jingquan Gao , Wei Huang , Hongli Sun  

Naunyn   Schmiedebergs Arch Pharmacol

2018.02

SCI

P2X4R promotes airway remodeling by acting on the phenotype switching of   bronchial smooth muscle cells in rats

Li Wang ,   Xiaoqian Feng , Bing Hu , Qingqing Xia , Xiuqin Ni , Yinli Song

Purinergic   Signal

2018.12

SCI

15-Lipoxygenase-2/15(S)-hydroxyeicosatetraenoic acid regulates cell   proliferation and metastasis via the STAT3 pathway in lung adenocarcinoma

Lin Yang , Cui   Ma , Lixin Zhang , Min Zhang , Fei Li , Chen Zhang , Xiufeng Yu , Xiaoying   Wang , Siyu He , Daling Zhu , Yinli Song

Prostaglandins   Other Lipid Mediat

2018.09

SCI

alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation   of pulmonary artery smooth muscle cells via CaMKII signaling.

Qian Luo ,   Xiaoyan Wang , Ruxia Liu , Hui Qiao , Peng Wang , Chao Jiang , Qianlong Zhang   , Yonggang Cao , Hang Yu , Lihui Qu

J Cell Biochem

2019.06

SCI

Potential Role of Cartilage Oligomeric 1 Matrix Protein in the   Modulation of
  Pulmonary Arterial Smooth Muscle Superoxide by Hypoxia

Hang Yu , Norah   Alruwaili , Bing Hu , Melissa R Kelly , Bin Zhang  , Dong Sun , Michael S Wolin

Am J Physiol   Lung Cell Mol Physiol

2019.11

SCI

Deletion of Neuropeptide Y
  Attenuates Cardiac Dysfunction
  and Apoptosis During Acute
  Myocardial Infarction

Wei Huang ,   Qianhui Zhang , Hanping Qi , Pilong Shi , Chao Song , Yongsheng Liu , Hongli   Sun

Front Pharmacol

2019.10

SCI

Long Noncoding RNA-Maternally Expressed Gene 3 Contributes to Hypoxic   Pulmonary Hypertension

Yan Xing ,   Xiaodong Zheng , Yao Fu , Jing Qi , Minghui Li , Mingfei Ma , Shuang Wang ,   Shuzhen Li , Daling Zhu

Mol Ther

2019.12

SCI

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced
  hippocampal neuronal impairment by ferroptosis mitigation

Xueying Guan ,   Xiaolei Li , Xuejiao Yang , Junwei Yan , Pilong Shi , Lina Ba , Yonggang Cao   , Peng Wang

Life Sci.

2019.10

SCI

Resveratrol inhibits lipid accumulation in the intestine of   atherosclerotic mice and macrophages.

Guozhu Ye,   Guoyou Chen, Han Gao, Yi Lin , Xu Liao, Han Zhang , Xinyu Liu , Yulang Chi ,   Qiansheng Huang , Huimin Zhu , Yuhua Fan , Sijun Dong

J Cell Mol Med

.

2019.06

SCI

mi R -15a/15b Cluster Modulates Survival of Mesenchymal Stem Cells to   Improve Its Therapeutic Efficacy of Myocardial Infarction.

Yingfeng Tu, Yan   Qiu , Li Liu , Tao Huang , Hao Tang , Youbin Liu , Wenguang Guo , Hongchi   Jiang , Yuhua Fan , Bo Yu

J Am Heart Assoc

.

2019.01

SCI

MiR-103 inhibiting cardiac hypertrophy through inactivation of   myocardial cell autophagy via targeting TRPV3 channel in rat hearts.

Hanping Qi ,   Jing Ren , Mingyao E , Qianhui Zhang , Yonggang Cao , Lina Ba , Chao Song ,   Pilong Shi , Bowen Fu , Hongli Sun

J Cell Mol Med

.

2019.03

SCI

Allicin attenuates pathological cardiac hypertrophy by inhibiting   autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling   pathways.

Lina Ba ,   Jingquan Gao , Yunping Chen , Hanping Qi , Chonghui Dong , Hao Pan , Qianhui Zhang   , Pilong Shi , Chao Song , Xueying Guan , Yonggang Cao , Hongli Sun

Phytomedicine

.

2019.05

SCI

Potential Role of Cartilage Oligomeric 1 Matrix Protein in the   Modulation of Pulmonary Arterial Smooth Muscle Superoxide by Hypoxia

Hang Yu , Norah Alruwaili   , Bing Hu 1, Melissa R Kelly , Bin Zhang , Dong Sun , Michael S Wolin

Am J Physiol   Lung Cell Mol Physiol

.

2019.11

SCI

alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation   of pulmonary artery smooth muscle cells via CaMKII signaling

Qian Luo ,   Xiaoyan Wang , Ruxia Liu , Hui Qiao , Peng Wang , Chao Jiang , Qianlong Zhang   , Yonggang Cao , Hang Yu 1, Lihui Qu

J Cell Biochem

.

2019.06

SCI

Deletion of Neuropeptide Y Attenuates Cardiac Dysfunction and Apoptosis   During Acute Myocardial Infarction

Wei Huang ,   Qianhui Zhang , Hanping Qi, Pilong Shi , Chao Song , Yongsheng Liu , Hongli   Sun

Front Pharmacol

.

2019.10

SCI

Novel lncRNA   PSMG3‑AS1   functions as a miR‑143‑3p sponge to increase the proliferation and migration of   breast cancer cells

Yue Cui , Yuhua   Fan , Guangcai Zhao , Qibing Zhang , Ying Bao , Yuanri Cui , Zengjie Ye ,   Guoyou Chen , Xianji Piao, Fang Guo , Jinghao Wang , Yuhua Bai , Dejun Yu

Oncol Rep.

2020.01

SCI

Electrical   stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via   sirtuin3 activation to promote autophagy and inhibit ROS generation

Lin Cong , Ziyu   Gao , Yinghong Zheng , Ting Ye , Zitong Wang , Pengyu Wang , Manman Li ,   Bowen Dong , Wei Yang , Quanfeng Li , Shupei Qiao , Cao Wang , Yijun Shen ,   Hong Li , Weiming Tian , Liming Yang

Aging (Albany   NY)

.

2020.04

SCI

Estradiol-Induced   MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive   Breast Cancer Cells

Yu Pan , Xiuli   Wang , Yanzhi Zhang , Juanjuan Qiao , Hironobu Sasano , Keely McNamara ,   Baoshan Zhao , Dongmei Zhang , Yuhua Fan , Lili Liu , Xueling Jia , Ming Liu   , Sihang Song , Lin Wang

Horm Cancer

.

2020.04

SCI

MSTN Attenuates Cardiac Hypertrophy through Inhibition of Excessive   Cardiac Autophagy by Blocking AMPK /mTOR and miR-128/PPARγ/NF-κB

Hanping Qi ,   Jing Ren , Lina Ba, Chao Song , Qianhui Zhang , Yonggang Cao , Pilong Shi ,   Bowen Fu , Yongsheng Liu , Hongli Sun

Mol Ther Nucleic   Acids

.

2020.03

SCI

The Vascular   Dilatation Induced by Hydroxysafflor yellow A (HSYA) on Rat Mesenteric Artery   Through TRPV4-dependent Calcium Influx in Endothelial Cell

Jianfeng Yang ,   Rui Wang , Xiaohan Cheng , HuiChong Qu , Jing Qi , Dan Li , Yan Xing , Yuhua Bai   , Xiaodong Zheng

J Ethnopharmacol

.

2020.06

SCI

Chemical   constituents from the fruits of Piper longum L. and their vascular relaxation   effect on rat mesenteric arteries

Dan Li , Rui   Wang , Xiaohan Cheng , Jianfeng Yang , Yihui Yang , Huichong Qu , Sen Li ,   Shan Lin , Donghua Wei , Yuhua Bai , Xiaodong Zheng

Nat Prod Res

.

2020.08

SCI

Inhibition of lncRNA   Gm15834 attenuates autophagy-mediated myocardial hypertrophy via miR-30b-3p/ULK1   axis in mice

Chao Song ,   Hanping Qi , Yongsheng Liu , Yunping Chen , Pilong Shi , Shu Zhang , Jing Ren   , Lixin Wang , Yonggang Cao , Hongli Sun

Mol Ther

.

2021.03

SCI

成果名称

完成人

奖励名称

 Galectin-3调节肺动脉高压大鼠血管外膜滋养血管形成中的网络机制

王晓艳

大庆市科技进步奖

 法医学社会服务与科学研究一体化平台建设 

王麟

大庆市科技进步奖

 药物介导的生物医学工程治疗动脉粥样硬化作用和机制探究 

杨力明

黑龙江省医药卫生科学技术奖

课题编号

立项名称

主持人

项目来源

执行年限

资助金额（万元）

81872856

心肌肥厚发生的新机制—lncRNA   Gm15834/miR-30b/ULK1/自噬调控网络参与心肌肥厚的作用及机制

孙宏丽

国家自然科学基金

2019.01-2023.12

57

2018M630378

MSTN通过miR-30e 和 AMPK/mTOR通路对心肌肥厚的作用研究

戚汉平

中国博士后科学基金项目

2018.09-2021.09

8

LH2019H009

剪切力对非小细胞肺癌细胞增殖和迁移影响的机制研究

曹永刚

黑龙江省自然科学基金

2019.7-2022.7

10

2019M661297

血管平滑肌收缩新机制：钙离子、细胞自噬诱导血管收缩

张彦秋

中国博士后科学基金项目

2019.10-2022.10

8

血管疾病新细胞分子靶点、模式动物和转化医学研究

郑晓东

中央支持地方高校发展基金-优秀青年人才支持计划

2019.12-2022.11

100

81973313

lncRNA   GAS5介导DNA甲基化在动脉粥样硬化中诱导巨噬细胞焦亡作用及机制研究

范玉华

国家自然科学基金

2020.1-2023.12

55

LH2020H031

PELP1调控GSDME焦亡参与乳腺癌对紫杉醇耐药的机制研究

王麟

黑龙江省自然科学基金

2020.7-2023.7

10

LH2020H027

环状RNA-Tnnc2通过调控自噬参与肺动脉平滑肌细胞增殖

曲丽辉

黑龙江省自然科学基金

2020.7-2023.7

10

91939104

联合OCT基于Galectin-3为靶点的褪黑素促TFEB去乙酰化诱导巨噬细胞自噬稳定动脉粥样硬化易损斑块的机制研究

杨力明

国家自然科学基金重大研究计划培育项目

2020.01-2021.12

45